Extracorporeal Photopheresis for Bronchiolitis Obliterans Syndrome After Lung Transplantation.

ABSTRACT:

Background

Lung transplantation is a therapeutic option for select patients with end-stage lung disease. However, successful lung transplantation is hampered by chronic lung allograft dysfunction, in particular bronchiolitis obliterans syndrome (BOS). Although there is no approved or standard treatment for BOS, which may have several distinct phenotypes, extracorporeal photopheresis (ECP) has shown promising results in patients who develop BOS refractory to azithromycin treatment.

Methods

We reviewed all relevant clinical data indexed on PubMed from 1987 to 2017 to evaluate the role of ECP in patients with BOS.

Results

Seven small studies investigated the immunomodulatory effects of ECP in patients after solid organ transplant, and 12 studies reported clinical data sp

SUBMITTER: Hachem R 

PROVIDER: S-EPMC7228625 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature