The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.

ABSTRACT: Organogenesis is directed by coordinated cell proliferation and differentiation programs. The hierarchical networks of transcription factors driving mammary gland development and function have been widely studied. However, the contribution of posttranscriptional gene expression reprogramming remains largely unexplored. The 3' untranslated regions of messenger RNAs (mRNAs) contain combinatorial ensembles of cis-regulatory elements that define transcript-specific regulation of protein synthesis through their cognate RNA binding proteins. We analyze the contribution of the RNA binding cytoplasmic polyadenylation element-binding (CPEB) protein family, which collectively regulate mRNA translation for about 30% of the genome. We find that CPEB2 is required for the integration of hormonal signali

SUBMITTER: Pascual R 

PROVIDER: S-EPMC7228762 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature