Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone.

ABSTRACT: The clinical administration of GABAergic medications leads to hypotension which has classically been attributed to the modulation of neuronal activity in the central and peripheral nervous systems. However, certain types of peripheral smooth muscle cells have been shown to express GABAA receptors, which modulate smooth muscle tone, by the activation of these chloride channels on smooth muscle cell plasma membranes. Limited prior studies demonstrate that non-human large-caliber capacitance blood vessels mounted on a wire myograph are responsive to GABAA ligands. We questioned whether GABAA receptors are expressed in human resistance arteries and whether they modulate myogenic tone. We demonstrate the novel expression of GABAA subunits on vascular smooth muscle from small-caliber human oment

SUBMITTER: Yim PD 

PROVIDER: S-EPMC7228859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature