Ontology highlight
ABSTRACT:
SUBMITTER: Qing T
PROVIDER: S-EPMC7228928 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200515 1
Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter the structure, expression, or function of protein-coding regions of cancer-biology related genes (gHFI) determines which and how many somatic mutations (sM) must occur for malignant transformation. We show that gHFI and sM affect overlapping genes and the average number of gHFI in cancer hallmark genes is higher in patients who develop cancer at a younger age (r = ...[more]