Dynamic resource allocation drives growth under nitrogen starvation in eukaryotes.

ABSTRACT: Cells can sense changes in their extracellular environment and subsequently adapt their biomass composition. Nutrient abundance defines the capability of the cell to produce biomass components. Under nutrient-limited conditions, resource allocation dramatically shifts to carbon-rich molecules. Here, we used dynamic biomass composition data to predict changes in growth and reaction flux distributions using the available genome-scale metabolic models of five eukaryotic organisms (three heterotrophs and two phototrophs). We identified temporal profiles of metabolic fluxes that indicate long-term trends in pathway and organelle function in response to nitrogen depletion. Surprisingly, our calculations of model sensitivity and biosynthetic cost showed that free energy of biomass metabolites is

SUBMITTER: Tibocha-Bonilla JD 

PROVIDER: S-EPMC7229059 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature