Impact of dead time on quantitative 177Lu-SPECT (QSPECT) and kidney dosimetry during PRRT.

ABSTRACT: BACKGROUND:Dead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on 177Lu-QSPECT and renal dosimetry following peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumours. METHODS:QSPECT/CT was performed on days 1 and 3 during 564 personalized 177Lu-octreotate cycles in 166 patients. The dead-time data for each scanning time point was compiled. The impact of not correcting QSPECT for the dead time was assessed for the kidney dosimetry. This was also estimated for empiric PRRT by simulating in our cohort a regime of 7.4 GBq/cycle. RESULTS:The probability to observe a larger dead time increased with the injected activity. A dead-time loss greater than 5% affected 14.4% and 5.7% of QSPE

SUBMITTER: Desy A 

PROVIDER: S-EPMC7229114 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature