Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients.

ABSTRACT: Cellular subpopulations within the colorectal tumor microenvironment (TME) include CD3⁺ and CD8⁺ lymphocytes, CD68⁺ and CD163⁺ macrophages, and tumor buds (TBs), all of which have known prognostic significance in stage II colorectal cancer. However, the prognostic relevance of their spatial interactions remains unknown. Here, by applying automated image analysis and machine learning approaches, we evaluate the prognostic significance of these cellular subpopulations and their spatial interactions. Resultant data, from a training cohort retrospectively collated from Edinburgh, UK hospitals (n = 113), were used to create a combinatorial prognostic model, which identified a subpopulation of patients who exhibit 100% survival over a 5-year fol

SUBMITTER: Nearchou IP 

PROVIDER: S-EPMC7229187 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature