Prediction of sleep side effects following methylphenidate treatment in ADHD youth.

ABSTRACT:

Objective

Sleep problems is the most common side effect of methylphenidate (MPH) treatment in ADHD youth and carry potential to negatively impact long-term self-regulatory functioning. This study aimed to examine whether applying machine learning approaches to pre-treatment demographic, clinical questionnaire, environmental, neuropsychological, genetic, and neuroimaging features can predict sleep side effects following MPH administration.

Method

The present study included 83 ADHD subjects as a training dataset. The participants were enrolled in an 8-week, open-label trial of MPH. The Barkley Stimulant Side Effects Rating Scale was used to determine the presence/absence of sleep problems at the 2nd week of treatment. Prediction of sleep side effects were performed with step-w

SUBMITTER: Yoo JH 

PROVIDER: S-EPMC7229354 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature