Repeated dose (90 days) oral toxicity study of ursolic acid in Han-Wistar rats.

ABSTRACT:

Background

Ursolic acid (UA) has been used in alternative medicine for decades, and there has been a great interest in its medicinal properties. Despite this increased interest, a detailed long-term toxicity study has not been performed. The objective of this study was to determine the long-term toxic effect of UA on clinical chemistry, haematology, coagulation, pathology/morphology, behaviour and motor skills in rats.

Methods

A solution was made by dissolving UA in a mixture of 0.1% Tween 80 and 0.5% hydroxypropyl methylcellulose in Milli-Q Water. The control group received the vehicle, and the test groups received a dose up to 1000 mg/kg/day via oral gavage. The solution was administered to both male and female (Han-Wistar) rats for 90 consecutive days.

Results

UA d

SUBMITTER: Geerlofs L 

PROVIDER: S-EPMC7229404 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature