Evaluating 2-[¹⁸F]FDG-PET in differential diagnosis of dementia using a data-driven decision model.

ABSTRACT: 2-[¹⁸F]fluoro-2-deoxy-d-glucose positron emission tomography (2-[¹⁸F]FDG-PET) has an emerging supportive role in dementia diagnostic as distinctive metabolic patterns are specific for Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). Previous studies have demonstrated that a data-driven decision model based on the disease state index (DSI) classifier supports clinicians in the differential diagnosis of dementia by using different combinations of diagnostic tests and biomarkers. Until now, this model has not included 2-[¹⁸F]FDG-PET data. The objective of the study was to evaluate 2-[¹⁸F]FDG-PET biomarkers combined with commonly used diagnostic tests in the differential diagnosis of dementia using the DSI

SUBMITTER: Gjerum L 

PROVIDER: S-EPMC7229490 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature