Influence of hemoadsorption during cardiopulmonary bypass on blood vesicle count and function.

ABSTRACT:

Background

Extracorporeal circulation during major cardiac surgery triggers a systemic inflammatory response affecting the clinical course and outcome. Recently, extracellular vesicle (EV) research has shed light onto a novel cellular communication network during inflammation. Hemoadsorption (HA) systems have shown divergent results in modulating the systemic inflammatory response during cardiopulmonary bypass (CPB) surgery. To date, the effect of HA on circulating microvesicles (MVs) in patients undergoing CPB surgery is unknown.

Methods

Count and function of MVs, as part of the extracellular vesicle fraction, were assessed in a subcohort of a single-center, blinded, controlled study investigating the effect of the CytoSorb device during CPB. A total of 18 patients undergoi

SUBMITTER: Wisgrill L 

PROVIDER: S-EPMC7229608 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature