Real-time surveillance of surgical margins via ICG-based near-infrared fluorescence imaging in patients with OSCC.

ABSTRACT:

Background

Local recurrence is the main cause of death among patients with oral squamous cell carcinoma (OSCC). This study assessed near-infrared fluorescence (NIF) imaging and spectroscopy to monitor surgical margins intraoperatively for OSCC.

Methods

Cytological and animal experiments were first performed to confirm the feasibility of monitoring surgical margins with NIF imaging and spectroscopy. Then, 20 patients with OSCC were included in the clinical trials. At 6-8 h after 0.75 mg/kg indocyanine green (ICG) injection, all patients underwent surgery with NIF imaging. During the surgery, both NIF images and quantified fluorescence intensity were acquired to monitor the surgical margins.

Results

In cytological and animal experiments, the results showed it was feasib

SUBMITTER: Pan J 

PROVIDER: S-EPMC7229610 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature