Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial.

ABSTRACT:

Background

Coronavirus disease 2019 (Covid-19) has resulted in a global outbreak. Few existing targeted medications are available. Lianhuaqingwen (LH) capsule, a repurposed marketed Chinese herb product, has been proven effective for influenza.

Purpose

To determine the safety and efficacy of LH capsule in patients with Covid-19.

Methods

We did a prospective multicenter open-label randomized controlled trial on LH capsule in confirmed cases with Covid-19. Patients were randomized to receive usual treatment alone or in combination with LH capsules (4 capsules, thrice daily) for 14 days. The primary endpoint was the rate of symptom (fever, fatigue, coughing) recovery.

Results

We included 284 patients (142 each in treatment and control group) in the full-analysis s

SUBMITTER: Hu K 

PROVIDER: S-EPMC7229744 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature