Co-Occurrence of mcr-9 and bla _NDM-1 in Enterobacter cloacae Isolated from a Patient with Bloodstream Infection.

ABSTRACT:

Background

Bloodstream infection (BSI) caused by carbapenem-resistant Enterobacteriaceae are potentially life-threatening related to poorer outcomes. Colistin is considered one of the last-resort treatments against human infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Therefore, emergence of strains from the blood that co-harboring mcr and carbapenem resistance genes were considered as a serious problem.

Purpose

In this study, two mcr-9-harboring MDR Enterobacter cloacae isolates BSI034 and BSI072 recovered from BSI patients were identified, one of which co-harbored mcr-9 and bla _NDM-1. The genetic characteristics of the MDR plasmid needed to be clarified.

Methods

S1-PFGE and Southern blotting were c

SUBMITTER: Lin M 

PROVIDER: S-EPMC7229791 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature