Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.

ABSTRACT:

Objective

This study was performed to explore the correlation between the characteristics of hepatitis B virus (HBV) quasispecies in HBV-infected pregnant women and the risk of immunoprophylaxis failure for their infants.

Design

In this prospective nested case-control study, the characteristics of HBV quasispecies in mothers whose infants were immunoprophylaxis success (control group) and those whose infants were immunoprophylaxis failure (case group) were analysed by the clone-based sequencing of full-length HBV genome and next-generation sequencing (NGS) of "a" determinant region, and were compared between the two groups.

Results

The quasispecies characteristics including mutant frequency, Shannon entropy and mean genetic distance at amino acid level of "a" determin

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC7229894 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature