Percutaneous coronary intervention versus medical therapy in patients with angina and grey-zone fractional flow reserve values: a randomised clinical trial.

ABSTRACT:

Introduction

There is conflicting evidence regarding the benefits of percutaneous coronary intervention (PCI) in patients with grey zone fractional flow reserve (^GZFFR artery) values (0.75-0.80). The prevalence of ischaemia is unknown. We wished to define the prevalence of ischaemia in ^GZFFR artery and assess whether PCI is superior to optimal medical therapy (OMT) for angina control.

Methods

We enrolled 104 patients with angina with 1:1 randomisation to PCI or OMT. The artery was interrogated with a Doppler flow/pressure wire. Patients underwent Magnetic Resonance Imaging (MRI) with follow-up at 3 and 12 months. The primary outcome was angina status at 3 months using the Seattle Angina Questionnaire (SAQ).

Results

104 patients (age 60±9 years),

SUBMITTER: Hennigan B 

PROVIDER: S-EPMC7229900 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature