Ontology highlight
ABSTRACT:
SUBMITTER: Farrow MA
PROVIDER: S-EPMC7230009 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Farrow Melissa A MA Chumber Nicole M NM Bloch Sarah C SC King McKenzie M Moton-Melancon Kaycei K Shupe John J Washington Mary K MK Spiller Benjamin W BW Lacy D Borden DB
ACS chemical biology 20200114 5
<i>Clostridioides difficile</i> is the leading cause of nosocomial diarrhea in the United States. The primary virulence factors are two homologous glucosyltransferase toxins, TcdA and TcdB, that inactivate host Rho-family GTPases. The glucosyltransferase activity has been linked to a "cytopathic" disruption of the actin cytoskeleton and contributes to the disruption of tight junctions and the production of pro-inflammatory cytokines. TcdB is also a potent cytotoxin that causes epithelium necroti ...[more]