SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data.

ABSTRACT: Many proteins are composed of several domains that pack together into a complex tertiary structure. Multidomain proteins can be challenging for protein structure modeling, particularly those for which templates can be found for individual domains but not for the entire sequence. In such cases, homology modeling can generate high quality models of the domains but not for the orientations between domains. Small-angle X-ray scattering (SAXS) reports the structural properties of entire proteins and has the potential for guiding homology modeling of multidomain proteins. In this article, we describe a novel multidomain protein assembly modeling method, SAXSDom that integrates experimental knowledge from SAXS with probabilistic Input-Output Hidden Markov model to assemble the structures of indiv

SUBMITTER: Hou J 

PROVIDER: S-EPMC7230021 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature