Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival.

ABSTRACT: OBJECTIVE:Reflux promotes esophageal adenocarcinomas (EACs) creating a chronic inflammatory environment. Survival rates are low due to early local recurrences and distant metastasis. Hence, there is a need for new potential treatment options like immunotherapies. However, the inflammatory microenvironment in EACs and its impact on patient outcome remain to be fully understood. METHODS:mRNA expression levels of pro- and anti-inflammatory markers in 39 EAC patients without neoadjuvant radio-chemotherapy were measured. Data were confirmed using flow cytometric analysis of freshly resected surgical specimens. Inflammatory alterations in premalignant lesions of Barrett's esophagus were analyzed by immunohistochemistry. RESULTS:Expression levels of IL22 were reduced in EAC, while expression leve

SUBMITTER: Karstens KF 

PROVIDER: S-EPMC7230052 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature