High MICB expression as a biomarker for good prognosis of colorectal cancer.

ABSTRACT:

Introduction

Major histocompatibility complex (MHC) plays an important role in colorectal cancer (CRC) immunity. However, the function of MHC class I chain-related B (MICB) molecule is not very clear. In this study, we explored the prognostic effect of MICB in colorectal cancer.

Material and methods

From 2008-05 to 2012-11, consecutive CRC patients of Zhongshan Hospital, Fudan University were retrospectively enrolled as primary cohort. The inclusion criteria were as follows: receiving primary radical resection, pathologically confirmed colorectal adenocarcinoma, no treatment before surgery, clinicopathological data available. Another cohort of CRC patients were collected from a public dataset GSE39582 of GEO database from 1987 to 2007 in the same criteria for validation. MIC

SUBMITTER: Feng Q 

PROVIDER: S-EPMC7230058 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature