Nebulized Heparin in Burn Patients with Inhalation Trauma-Safety and Feasibility.

ABSTRACT: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically be beneficial in patients with inhalation injury, but current data are conflicting. We aimed to investigate the safety, feasibility, and effectiveness of nebulized heparin. International multicenter, double-blind, placebo-controlled randomized clinical trial in specialized burn care centers. Adult patients with inhalation trauma received nebulizations of unfractionated heparin (25,000 international unit (IU), 5 mL) or placebo (0.9% NaCl, 5 mL) every four hours for 14 days or until extubation. The primary outcome was the number of ventilator-free days at day 28 post-admission. Here, we report on the secondary outcomes related to safety and feasibility. The study was prematurely stopped after

SUBMITTER: Glas GJ 

PROVIDER: S-EPMC7230289 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature