Use of pharmacogenomics in elderly patients treated for cardiovascular diseases.

ABSTRACT: Older people are increasingly susceptible to adverse drug reactions (ADRs) or therapeutic failure. This could be mediated by considerable polypharmacy, which increases the possibility of drug-drug and drug-gene interactions. Precision medicine, based on individual genetic variations, enables the screening of patients at risk for ADRs and the implementation of personalized treatment regimens. It combines genetic and genomic data with environmental and clinical factors in order to tailor prevention and disease-management strategies, including pharmacotherapy. The identification of genetic factors that influence drug absorption, distribution, metabolism, excretion, and action at the drug target level allows individualized therapy. Positive pharmacogenomic findings have been reported for the m

SUBMITTER: Bozina N 

PROVIDER: S-EPMC7230415 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature