Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics.

ABSTRACT: Viruses are widely used as a platform for the production of therapeutics. Vaccines containing live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key examples of clinically-approved therapeutic uses for viruses. Despite this, the use of virus-derived proteins as natural sources for immune modulators remains in the early stages of development. Viruses have evolved complex, highly effective approaches for immune evasion. Originally developed for protection against host immune responses, viral immune-modulating proteins are extraordinarily potent, often functioning at picomolar concentrations. These complex viral intracellular parasites have "performed the R&D", developing highly effective immune evasive strategies over millions of years. These proteins provid

SUBMITTER: Yaron JR 

PROVIDER: S-EPMC7230489 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature