Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial.

ABSTRACT: Treating sarcopenia in older individuals remains a challenge, and nutritional interventions present promising approaches in individuals that perform limited physical exercise. We assessed the efficacy of leucine administration to evaluate whether the regular intake of this essential amino acid can improve muscle mass, muscle strength and functional performance and respiratory muscle function in institutionalized older individuals. The study was a placebo-controlled, randomized, double-blind design in fifty participants aged 65 and over (ClinicalTrials.gov identifier NCT03831399). The participants were randomized to a parallel group intervention of 13 weeks' duration with a daily intake of leucine (6 g/day) or placebo (lactose, 6 g/day). The primary outcome was to study the effect on sarcop

SUBMITTER: Martinez-Arnau FM 

PROVIDER: S-EPMC7230494 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature