Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.

ABSTRACT: Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observa

SUBMITTER: Maretzke F 

PROVIDER: S-EPMC7231149 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature