High-Throughput Particle Concentration Using Complex Cross-Section Microchannels.

ABSTRACT: High throughput particle/cell concentration is crucial for a wide variety of biomedical, clinical, and environmental applications. In this work, we have proposed a passive spiral microfluidic concentrator with a complex cross-sectional shape, i.e., a combination of rectangle and trapezoid, for high separation efficiency and a confinement ratio less than 0.07. Particle focusing in our microfluidic system was observed in a single, tight focusing line, in which higher particle concentration is possible, as compared with simple rectangular or trapezoidal cross-sections with similar flow area. The sharper focusing stems from the confinement of Dean vortices in the trapezoidal region of the complex cross-section. To quantify this effect, we introduce a new parameter, complex focusing number or C

SUBMITTER: Mihandoust A 

PROVIDER: S-EPMC7231362 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature