IL28B genotype and the expression of ISGs in normal liver.

ABSTRACT:

Background & aims

Both polymorphisms in the IL28B gene locus and ISG expression levels are associated with the outcome of hepatitis C virus (HCV) infection. The two are also interrelated, although the mechanism is unknown. Favourable CC genotype at rs12979860 expresses lower baseline ISG levels and responds better to treatment than unfavourable CT and TT genotypes. Little is known about this relationship in normal, uninfected liver. This study sought to explore this relationship.

Methods

Normal human liver specimens (64) and HCV positive human liver specimens (95) were genotyped for IL28B rs12979860 C > T. mRNA levels of ISGs and other relevant genes were studied by qPCR.

Results

Most studied ISGs had significantly different expression by IL28B genotype in normal live

SUBMITTER: Raglow Z 

PROVIDER: S-EPMC7231429 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature