Clinical and neuropsychological profile of patients with dementia and chronic traumatic encephalopathy.

ABSTRACT:

Objective

To determine whether subjects with chronic traumatic encephalopathy (CTE) and dementia have distinct clinical features compared to subjects with pathologically confirmed Alzheimer's disease (AD).

Methods

Among 339 subjects assessed for CTE in the National Alzheimer's Coordinating Center dataset, 6 subjects with CTE and 25 subjects with AD neuropathologic change matched for age (±5 years) and sex were identified. All subjects had a clinical diagnosis of dementia. Neurological examination, neuropsychological testing and emotional/behavioural data were compared between CTE and AD subjects at the time of dementia diagnosis and last clinical visit near death.

Results

A history of traumatic brain injury with loss of consciousness (LOC) was reported in one CTE and

SUBMITTER: LoBue C 

PROVIDER: S-EPMC7231625 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature