Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs.

ABSTRACT: Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. However, insulin delivery systems with rapid in vivo glucose-responsive behaviour typically have limited insulin-loading capacities and cannot be manufactured easily. Here, we show that a single removable transdermal patch, bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabricated via in situ photopolymerization, regulated blood glucose in insulin-deficient diabetic mice and minipigs (for minipigs >25 kg, glucose regulation lasted >20 h with patches of ~5 cm²). Under hyperglycaemic conditions, phenylboronic acid units wi

SUBMITTER: Yu J 

PROVIDER: S-EPMC7231631 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature