Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease.

ABSTRACT:

Importance

Recent guidelines endorse using history of menopause before age 40 years to refine atherosclerotic cardiovascular disease risk assessments among middle-aged women. Robust data on cardiovascular disease risk in this population are lacking.

Objective

To examine the development of cardiovascular diseases and cardiovascular risk factors in women with natural and surgical menopause before age 40 years.

Design, setting, and participants

Cohort study (UK Biobank), with adult residents of the United Kingdom recruited between 2006 and 2010. Of women who were 40 to 69 years old and postmenopausal at study enrollment, 144 260 were eligible for inclusion. Follow-up occurred through August 2016.

Exposures

Natural premature menopause (menopause before age 40 witho

SUBMITTER: Honigberg MC 

PROVIDER: S-EPMC7231649 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature