Structural Description of the Nipah Virus Phosphoprotein and Its Interaction with STAT1.

ABSTRACT: The structural characterization of modular proteins containing long intrinsically disordered regions intercalated with folded domains is complicated by their conformational diversity and flexibility and requires the integration of multiple experimental approaches. Nipah virus (NiV) phosphoprotein, an essential component of the viral RNA transcription/replication machine and a component of the viral arsenal that hijacks cellular components and counteracts host immune responses, is a prototypical model for such modular proteins. Curiously, the phosphoprotein of NiV is significantly longer than the corresponding protein of other paramyxoviruses. Here, we combine multiple biophysical methods, including x-ray crystallography, NMR spectroscopy, and small angle x-ray scattering, to characterize t

SUBMITTER: Jensen MR 

PROVIDER: S-EPMC7231922 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature