Stearic acid methyl ester ​promotes migration of mesenchymal stem cells and accelerates cartilage defect repair.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homing is extremely limited. Thus, it has become extremely necessary to develop an agent or a method, which can be used to enhance the efficiency of MSCs homing. This study investigates the effect of stearic acid methyl ester (SAME) on MSCs mobilisation and cartilage regeneration.

Methods

MSCs were isolated from femurs of Sprague-Dawley (SD) rats. MTT assay was used to detect effect of SAME on via

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7231966 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature