Modulation of Pectin on Mucosal Innate Immune Function in Pigs Mediated by Gut Microbiota.

ABSTRACT: The use of prebiotics to regulate gut microbiota is a promising strategy to improve gut health. Pectin (PEC) is a prebiotic carbohydrate that enhances the health of the gut by promoting the growth of beneficial microbes. These microbes produce metabolites that are known to improve mucosal immune responses. This study was conducted to better understand effects of PEC on the microbiome and mucosal immunity in pigs. Pigs were fed two diets, with or without 5% apple PEC, for 72 days. Effects of PEC on the microbiota, cytokine expression, short-chain fatty acids (SCFAs) concentration and barrier function were examined in the ileum and cecum of the pigs. An integrative analysis was used to determine interactions of PEC consumption with bacterial metabolites and microbiome composition and host mu

SUBMITTER: Wu W 

PROVIDER: S-EPMC7232157 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature