Association between cancer antigen 19-9 and diabetes risk: A prospective and Mendelian randomization study.

ABSTRACT:

Aims/introduction

Elevated serum cancer antigen 19-9 (CA19-9) levels have been found in diabetes patients in most observational studies; however, whether there is a causal association between CA19-9 and diabetes mellitus is unclear.

Materials and methods

Our study was carried out based on the Dongfeng-Tongji cohort comprising 27,009 individuals. We first investigated the associations between serum CA19-9 levels and incident diabetes mellitus risk in a prospective cohort study (12,700 individuals). Then, we explored the potential causal relationship between CA19-9 and diabetes mellitus risk in a cross-sectional study (3,349 diabetes mellitus patients and 8,341 controls) using Mendelian randomization analysis. A weighted genetic risk score was calculated by adding the CA19-9 i

SUBMITTER: Li Z 

PROVIDER: S-EPMC7232271 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature