The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome.

ABSTRACT: Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range of biological processes such as biodegradation and biosynthesis, as well as immune function, fetal development, and physical and mental well-being. This work aimed to investigate the effect of iron deprivation in Toxoplasma gondii infection outcome. C57BL/6 mice were orally infected with T. gondii and treated with an iron chelator, deferoxamine, or supplemented with iron (ferrous sulfate), and the parasitism as well as immunological and histological parameters were analyzed. It was observed that the infection increased iron accumulation in the organs, as well as systemically, and deferoxamine treatment diminished the iron cont

SUBMITTER: Oliveira MC 

PROVIDER: S-EPMC7232304 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature