Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?

ABSTRACT: Potent antibody-mediated neutralization is critical for an organism to combat the vast array of pathogens it will face during its lifetime. Due to the potential genetic diversity of some viruses, such as HIV-1 and influenza, standard neutralizing antibodies are often ineffective or easily evaded as their targets are masked or rapidly mutated. This has thwarted efforts to both prevent and treat HIV-1 infections and means that entirely new formulations are required to vaccinate against influenza each year. However, some rare antibodies isolated from infected individuals confer broad and potent neutralization. A subset of these broadly neutralizing antibodies possesses a long complementarity-determining 3 region of the immunoglobulin heavy chain (CDR H3). This feature generates unique antigen

SUBMITTER: Burke MJ 

PROVIDER: S-EPMC7232318 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature