Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012-2019.

ABSTRACT: Influenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, co-circulate worldwide and they present challenges for vaccine strain selection. Until the present study, there was little information regarding the pattern of the circulating strains of IBV in Uruguay. A subset of positive influenza B samples from influenza-like illness (ILI) outpatients and severe acute respiratory illness (SARI) inpatients detected in sentinel hospitals in Uruguay during 2012-2019 were selected. The sequencing of the hemagglutinin (HA) and neuraminidase (NA) genes showed substitutions at the amino acid level. Phylogenetic analysis reveals the co-circulation of both lineage

SUBMITTER: Rivas MJ 

PROVIDER: S-EPMC7232498 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature