Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia.

ABSTRACT:

Background

The nature and timing of the host immune response during infections remain uncertain and most knowledge is derived from critically ill sepsis patients. We aimed to test the hypothesis that community-acquired pneumonia (CAP) is associated with concurrent immune suppression and systemic inflammation.

Methods

Blood was collected from 79 CAP patients within 24 h after hospitalization and 1 month after discharge; 42 age- and sex-matched subjects without acute infection served as controls. Blood leukocytes were stimulated with lipopolysaccharide (LPS) or Klebsiella pneumoniae, and cytokines were measured in supernatants. Fifteen plasma biomarkers reflective of key host response pathways were compared between CAP patients with the strongest immune suppression (low

SUBMITTER: Brands X 

PROVIDER: S-EPMC7232566 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature