Gene Coexpression Network and Module Analysis across 52 Human Tissues.

ABSTRACT: Gene coexpression analysis is widely used to infer gene modules associated with diseases and other clinical traits. However, a systematic view and comparison of gene coexpression networks and modules across a cohort of tissues are more or less ignored. In this study, we first construct gene coexpression networks and modules of 52 GTEx tissues and cell lines. The network modules are enriched in many tissue-common functions like organelle membrane and tissue-specific functions. We then study the correlation of tissues from the network point of view. As a result, the network modules of most tissues are significantly correlated, indicating a general similar network pattern across tissues. However, the level of similarity among the tissues is different. The tissues closing in a physical locatio

SUBMITTER: He B 

PROVIDER: S-EPMC7232734 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature