A classification framework for Bacillus anthracis defined by global genomic structure.

ABSTRACT: Bacillus anthracis, the causative agent of anthrax, is a considerable global health threat affecting wildlife, livestock, and the general public. In this study, whole-genome sequence analysis of over 350 B. anthracis isolates was used to establish a new high-resolution global genotyping framework that is both biogeographically informative and compatible with multiple genomic assays. The data presented in this study shed new light on the diverse global dissemination of this species and indicate that many lineages may be uniquely suited to the geographic regions in which they are found. In addition, we demonstrate that plasmid genomic structure for this species is largely consistent with chromosomal population structure, suggesting vertical inheritance in this bacterium has con

SUBMITTER: Bruce SA 

PROVIDER: S-EPMC7232756 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature