Validation and noninvasive kinetic modeling of [¹¹C]UCB-J PET imaging in mice.

ABSTRACT: Synaptic pathology is associated with several brain disorders, thus positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) using the radioligand [¹¹C]UCB-J may provide a tool to measure synaptic alterations. Given the pivotal role of mouse models in understanding neuropsychiatric and neurodegenerative disorders, this study aims to validate and characterize [¹¹C]UCB-J in mice. We performed a blocking study to verify the specificity of the radiotracer to SV2A, examined kinetic models using an image-derived input function (IDIF) for quantification of the radiotracer, and investigated the in vivo metabolism. Regional TACs during baseline showed rapid uptake of [¹¹C]UCB-J into the brain. Pretreatment with levetiracetam confirmed ta

SUBMITTER: Bertoglio D 

PROVIDER: S-EPMC7232782 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature