Allostatic load in the association of depressive symptoms with incident coronary heart disease: The Jackson Heart Study.

ABSTRACT: African Americans are at heightened risk for coronary heart disease (CHD), with biologic pathways poorly understood. We examined the role of allostatic load (AL) in the association of depressive symptoms with incident CHD among 2,670 African American men and women in the prospective Jackson Heart Study. Depressive symptoms were quantified using the Center for Epidemiologic Studies Depression Scale (CES-D). Incident CHD was ascertained by self-report, death certificate survey, and adjudicated medical record surveillance. Baseline AL was quantified using biologic parameters of metabolic, cardiovascular, immune, and neuroendocrine subsystems and as a combined meta-factor. Sequential models adjusted for demographic, socioeconomic, and behavioral covariates, stratified to examine differences by

SUBMITTER: Gillespie SL 

PROVIDER: S-EPMC7232849 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature