Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio.

ABSTRACT:

Background

Epidemiological studies report fairly consistent associations between various air pollution metrics and autism spectrum disorder (ASD), with some elevated risks reported for different prenatal and postnatal periods.

Objectives

To examine associations between ASD and ambient fine particulate matter (PM_2.5) and ozone concentrations during the prenatal period through the second year of life in a case-control study.

Methods

ASD cases (n = 428) diagnosed at Cincinnati Children's Hospital Medical Center were frequency matched (15:1) to 6420 controls from Ohio birth records. We assigned daily PM_2.5 and ozone estimates for 2005-2012 from US EPA's Fused Air Quality Surface Using Downscaling model to each participant for each day based on the mo

SUBMITTER: Kaufman JA 

PROVIDER: S-EPMC7232936 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature