Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) can manifest as a viral-induced hyperinflammation with multiorgan involvement. Such patients often experience rapid deterioration and need for mechanical ventilation. Currently, no prospectively validated biomarker of impending respiratory failure is available.

Objective

We aimed to identify and prospectively validate biomarkers that allow the identification of patients in need of impending mechanical ventilation.

Methods

Patients with COVID-19 who were hospitalized from February 29 to April 9, 2020, were analyzed for baseline clinical and laboratory findings at admission and during the disease. Data from 89 evaluable patients were available for the purpose of analysis comprising an initial evaluation cohort (n = 40) foll

SUBMITTER: Herold T 

PROVIDER: S-EPMC7233239 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature