Antibacterial action of nitric oxide-releasing hyperbranched polymers against ex vivo dental biofilms.

ABSTRACT:

Objectives

This study investigates the antibiofilm action of nitric oxide (NO)-releasing hyperbranched polymers against ex vivo multispecies periodontal biofilms.

Methods

The antibiofilm efficacy of NO-releasing hyperbranched polymers was evaluated as a function of NO-release properties, polymer concentrations, and oxygen levels in the exposure media. 16s rRNA sequencing technique was employed to evaluate the impact of NO-releasing hyperbranched polymers on the microbial composition of the biofilms.

Results

The addition of NO release significantly improved the antibiofilm action of the hyperbranched polymers, with NO-releasing hyperbranched polyamidoamines of largest NO payloads being more effective than hyperbranched polykanamycins. Furthermore, the NO-releasing hype

SUBMITTER: Yang L 

PROVIDER: S-EPMC7233373 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature