Amyloid accumulation in Down syndrome measured with amyloid load.

ABSTRACT:

Introduction

Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load (Aβ_L ) was recently developed as an alternative to standardized uptake value ratios (SUVrs) to quantify Aβ burden with high sensitivity for detecting and tracking Aβ change.¹.

Methods

Aβ_L was calculated in a DS cohort (N = 169, mean age ± SD = 39.6 ± 8.7 years) using [C-11]Pittsburgh compound B (PiB) PET imaging. DS-specific PiB templates were created for Aβ carrying capacity (K) and non-specific binding (NS).

Results

The highest values of Aβ carrying capacity were found in the striatum and precuneus. Longitudinal changes in Aβ_L

SUBMITTER: Zammit MD 

PROVIDER: S-EPMC7233422 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature