Hydrolyzed Ce(IV) salts limit sucrose-dependent biofilm formation by Streptococcus mutans.

ABSTRACT: Several studies have focused on the antimicrobial effects of cerium oxide nanoparticles (CeO₂-NP) but few have focused on their effects on bacteria under initial biofilm formation conditions. Streptococcus mutans is a prolific biofilm former contributing to dental caries in the presence of fermentable carbohydrates and is a recognized target for therapeutic intervention. CeO₂-NP derived solely from Ce(IV) salt hydrolysis were found to reduce adherent bacteria by approximately 40% while commercial dispersions of "bare" CeO₂-NP (e.g., 3 nm, 10-20 nm, 30 nm diameter) and Ce(NO₃)₃·6H₂O were either inactive or observed to slightly increase biofilm formation under similar in vitro conditions. Planktonic growth and dispersal assays

SUBMITTER: Bhatt L 

PROVIDER: S-EPMC7233464 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature