Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (tree shrew).

ABSTRACT: Mammary gland cancer is the most common cancer occurring in women globally. Incidences of this cancer in Japan are on the increase. Annually, more than 70,000 new cases are recorded in Japan and about 1.7 million in the world. Many cases are still difficult to cure completely, and animal models are required for the characterization of the biology, therapeutic strategy, and preventive measures for spontaneous mammary tumor. The mouse model used currently has some limitations owing to structural differences between mouse and human mammary glands. Tupaia belangeri (tree shrew), which belongs to the Tupaiidae family, shows relatively high genetic homology and structural similarity to human mammary glands. Here, we characterized the spontaneous mammary tumors in 61 female tree shrews of differe

SUBMITTER: Hai-Ying C 

PROVIDER: S-EPMC7233572 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature