Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration.

ABSTRACT: A green fabrication process (organic solvent-free) of artificial scaffolds is required in tissue engineering field. In this work, a series of aligned three-dimensional (3D) scaffolds are made from biodegradable waterborne polyurethane (PU) emulsion via directional freeze-drying method to ensure no organic byproducts. After optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures, an aligned PUs scaffold (PU14) generated from 14 wt% polymer content and processed at -196°C was selected based on the desired oriented porous structure (pore size of 32.5 ± 9.3 μm, porosity of 92%) and balanced mechanical properties both in the horizontal direction (strength of 41.3 kPa, modulus of 72.3 kPa) and in the vertical direction (strength of 45.5 kPa, modu

SUBMITTER: Lin W 

PROVIDER: S-EPMC7233617 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature