Ghrelin receptor in agouti-related peptide neurones regulates metabolic adaptation to calorie restriction.

ABSTRACT: Ghrelin is a gut hormone that signals to the hypothalamus to stimulate growth hormone release, increase food intake and promote fat deposition. The ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R), is highly expressed in the brain, with the highest expression in agouti-related peptide (AgRP) neurones in the hypothalamus. Compelling evidence indicates that ghrelin serves as a survival hormone with respect to maintaining blood glucose and body weight during nutritional deficiencies. Recent studies have demonstrated that AgRP neurones are involved in metabolic and behavioural adaptation to an energy deficit to improve survival. In the present study, we used a neuronal subtype-specific GHS-R knockout mouse (AgRP-Cre;Ghsr^f/f ) to investigate the role of GH

SUBMITTER: Wu CS 

PROVIDER: S-EPMC7233797 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature